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Some studies have concurrently employed cerebral blood flow perfusion imaging, revealing that the hypometabolic regions extend beyond those with reduced perfusion, suggesting the presence of intrinsic mitochondrial dysfunction in neurons (165)

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161 Recently, increasing evidence has suggested that lactate-derived lactylation occurs naturally and coordinates various physiological processes, such as somatic cell reprogramming, embryonic development, neural development, and cochlear development (Fig

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